In vitro therapeutic effects and molecular mechanisms of targeted inhibition of CDK12/13 in high-grade gliomas

In vitro therapeutic effects and molecular mechanisms of targeted inhibition of CDK12/13 in high-grade gliomas

Objective·To find novel and common targeting strategies for high-grade gliomas (HGGs) from the perspective of epigenetic and transcriptional modulators, test the therapeutic effect in vitro and investigate the related molecular mechanisms.Methods·Glioblastoma (GBM) and diffuse intrinsic pontine glio...

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Bibliographic Details
Main Authors: MEI Yanqing, HAN Yujie, WENG Wenyun, ZHANG Lei, TANG Yujie
Format: Article
Language:zho
Published: Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2023-05-01
Series:Shanghai Jiaotong Daxue xuebao. Yixue ban
Subjects:
glioblastoma (gbm)
diffuse intrinsic pontine glioma (dipg)
molecular targeted therapy
anti-tumor drug screening
crispr-cas9
cdk12
cdk13
Online Access:https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-545.shtml

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https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-545.shtml

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