Canagliflozin Ameliorates NLRP3 Inflammasome-Mediated Inflammation Through Inhibiting NF-κB Signaling and Upregulating Bif-1

Canagliflozin Ameliorates NLRP3 Inflammasome-Mediated Inflammation Through Inhibiting NF-κB Signaling and Upregulating Bif-1

NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is an important component of the innate immune system that mediates the secretion of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. However, current studies have shown that the abnormal activation of the NLRP3 i...

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Bibliographic Details
Main Authors: Yaoyun Niu, Yuehui Zhang, Wanqiu Zhang, Jinghua Lu, Yang Chen, Wenhui Hao, Jin Zhou, Lijun Wang, Weidong Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
canagliflozin
NLPR3
inflammasome
NF-κB
Bif-1
pneumonia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.820541/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.820541/full

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