Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening

Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening

A major bottleneck in the successful development of central nervous system (CNS) drugs is the discovery and design of molecules that can cross the blood-brain barrier (BBB). Nano-delivery strategies are a promising approach that take advantage of natural portals of entry into the brain such as monoc...

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Bibliographic Details
Main Authors: Sandra Isabel Aguiar, Joana N. R. Dias, Ana Santos André, Marta Lisete Silva, Diana Martins, Belmira Carrapiço, Miguel Castanho, João Carriço, Marco Cavaco, Maria Manuela Gaspar, Rui Jorge Nobre, Luís Pereira de Almeida, Soraia Oliveira, Lurdes Gano, João D. G. Correia, Carlos Barbas, João Gonçalves, Vera Neves, Frederico Aires-da-Silva
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
brain targeting antibodies
blood-brain barrier
in vivo phage display
single-domain antibodies
drug delivery
Online Access:https://www.mdpi.com/1999-4923/13/10/1598

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https://www.mdpi.com/1999-4923/13/10/1598

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