Fat transplantation induces dermal adipose regeneration and reverses skin fibrosis through dedifferentiation and redifferentiation of adipocytes

Fat transplantation induces dermal adipose regeneration and reverses skin fibrosis through dedifferentiation and redifferentiation of adipocytes

Abstract Background Localized scleroderma causes cosmetic disfigurement, joint contractures, and other functional impairment, but no currently available medications can reverse the resulting skin lesions. Fat grafting is beneficial for reversing skin fibrosis; however, the mechanism by which adipose...

Full description

Bibliographic Details
Main Authors: Jing Wang, Junrong Cai, Qian Zhang, Jiaqing Wen, Yunjun Liao, Feng Lu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Stem Cell Research & Therapy
Subjects:
Scleroderma
Fat grafting
Adipocyte
Dedifferentiated adipocyte
Adipose-derived stem cell
Online Access:https://doi.org/10.1186/s13287-022-03127-0

Internet

https://doi.org/10.1186/s13287-022-03127-0

Similar Items