Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6

Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6

KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding sites of this kinesin-6 has been reported, but little is known about ho...

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Bibliographic Details
Main Authors: Fanomezana Moutse Ranaivoson, Vincent Crozet, Matthieu P. M. H. Benoit, Amna Abdalla Mohammed Khalid, Carlos Kikuti, Helena Sirkia, Ahmed El Marjou, Stéphanie Miserey-Lenkei, Ana B. Asenjo, Hernando Sosa, Christoph F. Schmidt, Steven S. Rosenfeld, Anne Houdusse
Format: Article
Language:English
Published: The Royal Society 2023-09-01
Series:Open Biology
Subjects:
kinesin
KIF20A
motor activity
microtubule assembly
cytokinesis
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.230122

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.230122

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