Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isolates Leads to Frequent Development of Broad and Elite Antibody Neutralization in HIV-1-Infected Individuals

Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isolates Leads to Frequent Development of Broad and Elite Antibody Neutralization in HIV-1-Infected Individuals

ABSTRACT A minority of HIV-1-infected patients produce broadly neutralizing antibodies (bNAbs). Identification of viral and host correlates of bNAb production may help develop vaccines. We aimed to characterize the neutralizing response and viral and host-associated factors in Angola, which has one...

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Bibliographic Details
Main Authors: Francisco Martin, José Maria Marcelino, Claudia Palladino, Inês Bártolo, Susana Tracana, Inês Moranguinho, Paloma Gonçalves, Rita Mateus, Rita Calado, Pedro Borrego, Thomas Leitner, Sofia Clemente, Nuno Taveira
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
Angola
Env diversity
HIV-1 infection
broadly neutralizing antibodies
bNAbs
Env-specific antibodies
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01634-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01634-22

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