Impaired activation of plasmacytoid dendritic cells via toll-like receptor 7/9 and STING is mediated by melanoma-derived immunosuppressive cytokines and metabolic drift

Impaired activation of plasmacytoid dendritic cells via toll-like receptor 7/9 and STING is mediated by melanoma-derived immunosuppressive cytokines and metabolic drift

IntroductionPlasmacytoid dendritic cells (pDCs) infiltrate a large set of human cancers. Interferon alpha (IFN-α) produced by pDCs induces growth arrest and apoptosis in tumor cells and modulates innate and adaptive immune cells involved in anti-cancer immunity. Moreover, effector molecules exert tu...

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Bibliographic Details
Main Authors: Matilde Monti, Giorgia Ferrari, Valentina Grosso, Francesco Missale, Mattia Bugatti, Valeria Cancila, Stefania Zini, Agnese Segala, Luca La Via, Francesca Consoli, Matteo Orlandi, Alessandra Valerio, Claudio Tripodo, Marzia Rossato, William Vermi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
melanoma
plasmacytoid dendritic cells
toll-like receptor
interferon
cGAS-STING
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1227648/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1227648/full

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