A medium-chain triglyceride containing ketogenic diet exacerbates cardiomyopathy in a CRISPR/Cas9 gene-edited rat model with Duchenne muscular dystrophy

A medium-chain triglyceride containing ketogenic diet exacerbates cardiomyopathy in a CRISPR/Cas9 gene-edited rat model with Duchenne muscular dystrophy

Abstract Duchenne muscular dystrophy (DMD) is an X-linked recessive myopathy caused by dystrophin mutations. Although respiratory management has improved the prognosis of patients with DMD, inevitable progressive cardiomyopathy is a current leading cause of premature death. Recently, we showed that...

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Bibliographic Details
Main Authors: Yuri Fujikura, Koichi Kimura, Keitaro Yamanouchi, Hidetoshi Sugihara, Masaki Hatakeyama, Haotong Zhuang, Tomoki Abe, Masao Daimon, Hiroyuki Morita, Issei Komuro, Katsutaka Oishi
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15934-9

Internet

https://doi.org/10.1038/s41598-022-15934-9

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