Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes

Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes

Trained immunity refers to the long-lasting memory traits of innate immunity. Recent studies have shown that trained immunity is orchestrated by sustained changes in epigenetic marks and metabolic pathways, leading to an altered transcriptional response to a second challenge. However, the potential...

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Bibliographic Details
Main Authors: Bowen Zhang, Simone J.C.F.M Moorlag, Jorge Dominguez-Andres, Özlem Bulut, Gizem Kilic, Zhaoli Liu, Reinout van Crevel, Cheng-Jian Xu, Leo A.B. Joosten, Mihai G. Netea, Yang Li
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-04-01
Series:The Journal of Clinical Investigation
Subjects:
Immunology
Infectious disease
Online Access:https://doi.org/10.1172/JCI147719

Internet

https://doi.org/10.1172/JCI147719

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