Carnosic Acid Alleviates Levodopa-Induced Dyskinesia and Cell Death in 6-Hydroxydopamine-lesioned Rats and in SH-SY5Y Cells

Carnosic Acid Alleviates Levodopa-Induced Dyskinesia and Cell Death in 6-Hydroxydopamine-lesioned Rats and in SH-SY5Y Cells

The present study investigated the impact of carnosic acid (CA) from rosemary on the levodopa (L-dopa)-induced dyskinesia (LID) in rats treated with 6-hydroxydopamine (6-OHDA). To establish the model of LID, 6-OHDA-lesioned rats were injected intraperitoneally with 30 mg/kg L-dopa once a day for 36 ...

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Bibliographic Details
Main Authors: Chun-Yi Lai, Chia-Yuan Lin, Chi-Rei Wu, Chon-Haw Tsai, Chia-Wen Tsai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
carnosic acid
6-hydroxydopamine
levodopa-induced dyskinesia
DARPP-32/ΔFosB
ERK1/2-c-jun
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.703894/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.703894/full

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