Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors

Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors

As a novel and promising antitumor target, AXL plays an important role in tumor growth, metastasis, immunosuppression and drug resistance of various malignancies, which has attracted extensive research interest in recent years. In this study, by employing the structure-based drug design and bioisost...

Full description

Bibliographic Details
Main Authors: Feifei Fang, Yang Dai, Hao Wang, Yinchun Ji, Xuewu Liang, Xia Peng, Jiyuan Li, Yangrong Zhao, Chunpu Li, Danyi Wang, Yazhou Li, Dong Zhang, Dan Zhang, Meiyu Geng, Hong Liu, Jing Ai, Yu Zhou
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide derivatives
Antitumor drug development
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003854

Internet

http://www.sciencedirect.com/science/article/pii/S2211383523003854

Similar Items