New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases

New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases

The primary cause(s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown. However, the association of certain etiological factors, e.g., oxidative stress, protein misfolding/aggregation, redox metal accumulation and various...

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Bibliographic Details
Main Authors: Joy Mitra, Erika N. Guerrero, Pavana M. Hegde, Haibo Wang, Istvan Boldogh, Kosagi Sharaf Rao, Sankar Mitra, Muralidhar L. Hegde
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Biomolecules
Subjects:
redox transition metals
heavy metals
DNA base excision repair
metal toxicity
metal homeostasis
neurodegeneration
Alzheimer’s disease
Parkinson’s disease
Online Access:http://www.mdpi.com/2218-273X/4/3/678

Internet

http://www.mdpi.com/2218-273X/4/3/678

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