Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture

Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture

We created and studied new cybrid cell lines from sporadic Alzheimer's disease (SAD) or control (CTL) subjects to assess mitochondrial abnormalities just after metabolic selection (“early passage”) and again six passages later (“late passage”). Cytochrome oxidase (CO) activities in early passag...

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Bibliographic Details
Main Authors: Patricia A. Trimmer, Paula M. Keeney, M.Kate Borland, Frederic A. Simon, Jatanna Almeida, Russell H. Swerdlow, Janice P. Parks, W.Davis Parker, Jr., James P. Bennett, Jr.
Format: Article
Language:English
Published: Elsevier 2004-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Cybrids
mtDNA
Bioenergetic phenotype
Replicative advantage
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610300192X

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http://www.sciencedirect.com/science/article/pii/S096999610300192X

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