Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

Alterations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the most common pediatric brain tumor. Although inhibitors targeting the membrane protein Smoothened suppress Hh signaling, acquired drug resistance and tumor relapse call for additional therapeutic t...

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Bibliographic Details
Main Authors: Xuecai Ge, Ljiljana Milenkovic, Kaye Suyama, Tom Hartl, Teresa Purzner, Amy Winans, Tobias Meyer, Matthew P Scott
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
Hedgehog signal transduction
Semaphorin 3
Neuropilin
medulloblastoma
Phosphodiesterase 4D
tumors resistant to Smo-inhibitor
Online Access:https://elifesciences.org/articles/07068

Internet

https://elifesciences.org/articles/07068

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