Deconvolution of B cell receptor repertoire in multiple sclerosis patients revealed a delay in tBreg maturation

Deconvolution of B cell receptor repertoire in multiple sclerosis patients revealed a delay in tBreg maturation

BackgroundB lymphocytes play a pivotal regulatory role in the development of the immune response. It was previously shown that deficiency in B regulatory cells (Bregs) or a decrease in their anti-inflammatory activity can lead to immunological dysfunctions. However, the exact mechanisms of Bregs dev...

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Bibliographic Details
Main Authors: Yakov A. Lomakin, Ivan V. Zvyagin, Leyla A. Ovchinnikova, Marsel R. Kabilov, Dmitriy B. Staroverov, Artem Mikelov, Alexey E. Tupikin, Maria Y. Zakharova, Nadezda A. Bykova, Vera S. Mukhina, Alexander V. Favorov, Maria Ivanova, Taras Simaniv, Yury P. Rubtsov, Dmitriy M. Chudakov, Maria N. Zakharova, Sergey N. Illarioshkin, Alexey A. Belogurov, Alexander G. Gabibov
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
B regulatory cells
BCR
CD19+CD24highCD38high
multiple sclerosis
MS
transitional Breg
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.803229/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.803229/full

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