Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant

Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant

Abstract Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it is unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. Here, we transplant a gene-edited pig kidney into a brain-dead human recipient on pharmacolog...

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Bibliographic Details
Main Authors: Matthew D. Cheung, Rebecca Asiimwe, Elise N. Erman, Christopher F. Fucile, Shanrun Liu, Chiao-Wang Sun, Vidya Sagar Hanumanthu, Harish C. Pal, Emma D. Wright, Gelare Ghajar-Rahimi, Daniel Epstein, Babak J. Orandi, Vineeta Kumar, Douglas J. Anderson, Morgan E. Greene, Markayla Bell, Stefani Yates, Kyle H. Moore, Jennifer LaFontaine, John T. Killian, Gavin Baker, Jackson Perry, Zayd Khan, Rhiannon Reed, Shawn C. Little, Alexander F. Rosenberg, James F. George, Jayme E. Locke, Paige M. Porrett
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47454-7

Internet

https://doi.org/10.1038/s41467-024-47454-7

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