Multiscale modeling of collective cell migration elucidates the mechanism underlying tumor–stromal interactions in different spatiotemporal scales

Abstract Metastasis is the pathogenic spread of cancer cells from a primary tumor to a secondary site which happens at the late stages of cancer. It is caused by a variety of biological, chemical, and physical processes, such as molecular interactions, intercellular communications, and tissue-level...

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Bibliographic Details
Main Authors: Zarifeh Heidary, Shaghayegh Haghjooy Javanmard, Iman Izadi, Nasrin Zare, Jafar Ghaisari
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20634-5