FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression

FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression

Summary: PI3K regulatory subunit p85s normally stabilizes and regulates catalytic subunit p110s in the cytoplasm. Recent studies show that p110-free p85s in the nucleus plays important roles in biological processes. However, the mechanisms by which p85s translocate into the nucleus remain elusive. H...

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Bibliographic Details
Main Authors: Yanhua Zhang, Baoyu He, Dong Zhang, Yifan Zhang, Chengkun Chen, Wenye Zhang, Shiyi Yang, Meilian Yao, Gaoping Cui, Jun Gu, Ting Wang, Zhang Lin, Youben Fan, Zuquan Xiong, Yujun Hao
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723001997

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http://www.sciencedirect.com/science/article/pii/S2211124723001997

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