Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs

Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs

The muscarinic acetylcholine receptor family is a highly sought-after target in drug and molecular imaging discovery efforts aimed at neurological disorders. Hampered by the structural similarity of the five subtypes’ orthosteric binding pockets, these efforts largely failed to deliver subtype-selec...

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Bibliographic Details
Main Authors: Jonas Kilian, Marlon Millard, Marius Ozenil, Dominik Krause, Khadija Ghaderi, Wolfgang Holzer, Ernst Urban, Helmut Spreitzer, Wolfgang Wadsak, Marcus Hacker, Thierry Langer, Verena Pichler
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
muscarinic acetylcholine receptors
drug development
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/10/3173

Internet

https://www.mdpi.com/1420-3049/27/10/3173

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