PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[<sup>18</sup>F]fluoro-6-deoxy-D-fructose

PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[<sup>18</sup>F]fluoro-6-deoxy-D-fructose

Fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[<sup>18</sup>F]FDF) targets the fructose-preferred facilitative hexose transporter GLUT5, which is expressed predominantly in brain microglia and activated in response to inflammatory stimuli. We hypothesize that 6-[<sup>18</su...

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Bibliographic Details
Main Authors: Amanda J. Boyle, Emily Murrell, Junchao Tong, Christin Schifani, Andrea Narvaez, Melinda Wuest, Frederick West, Frank Wuest, Neil Vasdev
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
fructose
neuroinflammation
PET
fluorine-18
GLUT5
microglia
Online Access:https://www.mdpi.com/1420-3049/27/23/8529

Internet

https://www.mdpi.com/1420-3049/27/23/8529

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