Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer

Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer

Abstract Background Ovarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need for chemotherapy. Ovarian cancer is frequently sensitive to chemotherapy...

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Bibliographic Details
Main Authors: Taryne Chong, Amila Sarac, Cindy Q. Yao, Linda Liao, Nicola Lyttle, Paul C. Boutros, John M. S. Bartlett, Melanie Spears
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Ovarian Research
Subjects:
Spindle assembly checkpoint
Ovarian cancer
Paclitaxel
Mitotic checkpoint serine/threonine kinase (BUB1)
centromere protein E (CENPE)
Centromere protein F (CENPF)
Online Access:http://link.springer.com/article/10.1186/s13048-018-0399-7

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http://link.springer.com/article/10.1186/s13048-018-0399-7

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