Sequential Dynamics of Stearoyl-CoA Desaturase-1(SCD1)/Ligand Binding and Unbinding Mechanism: A Computational Study

Sequential Dynamics of Stearoyl-CoA Desaturase-1(SCD1)/Ligand Binding and Unbinding Mechanism: A Computational Study

Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome. This transmembrane endoplasmic reticulum protein converts saturated f...

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Bibliographic Details
Main Authors: Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng, Jerome Baudry
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomolecules
Subjects:
stearoyl-CoA desaturase-1
delta-9 desaturase
membrane protein
molecular dynamics
desaturase
molecular modeling
Online Access:https://www.mdpi.com/2218-273X/11/10/1435

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https://www.mdpi.com/2218-273X/11/10/1435

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