Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis

Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis

The human endogenous retrovirus (HERV)-K, human mouse mammary tumor virus like-2 (HML-2) subgroup of HERVs is activated in several tumors and has been related to prostate cancer progression and motor neuron diseases. The cellular splicing factor 2/alternative splicing factor (SF2/ASF) is a positive...

Full description

Bibliographic Details
Main Authors: Gabriele Ibba, Claudia Piu, Elena Uleri, Caterina Serra, Antonina Dolei
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Viruses
Subjects:
human endogenous retroviruses
HERV-Kenv
CRISPR/Cas9 gene-editing
prostate cancer
amyotrophic lateral sclerosis
pathogenesis
SF2/ASF
TDP-43
Online Access:http://www.mdpi.com/1999-4915/10/8/412

Internet

http://www.mdpi.com/1999-4915/10/8/412

Similar Items