Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth
Preterm birth results in premature exposure of the brain to the extrauterine environment during a critical period of neurodevelopment. Consequently, infants born preterm are at a heightened risk of adverse behavioural outcomes in later life. We characterise longitudinal development of neonatal regio...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323000555 |
| _version_ | 1827923926485827584 |
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| author | Lucy Vanes Sunniva Fenn-Moltu Laila Hadaya Sean Fitzgibbon Lucilio Cordero-Grande Anthony Price Andrew Chew Shona Falconer Tomoki Arichi Serena J. Counsell Joseph V. Hajnal Dafnis Batalle A. David Edwards Chiara Nosarti |
| author_facet | Lucy Vanes Sunniva Fenn-Moltu Laila Hadaya Sean Fitzgibbon Lucilio Cordero-Grande Anthony Price Andrew Chew Shona Falconer Tomoki Arichi Serena J. Counsell Joseph V. Hajnal Dafnis Batalle A. David Edwards Chiara Nosarti |
| author_sort | Lucy Vanes |
| collection | DOAJ |
| description | Preterm birth results in premature exposure of the brain to the extrauterine environment during a critical period of neurodevelopment. Consequently, infants born preterm are at a heightened risk of adverse behavioural outcomes in later life. We characterise longitudinal development of neonatal regional brain volume and functional connectivity in the first weeks following preterm birth, sociodemographic factors, and their respective relationships to psychomotor outcomes and psychopathology in toddlerhood. We study 121 infants born preterm who underwent magnetic resonance imaging shortly after birth, at term-equivalent age, or both. Longitudinal regional brain volume and functional connectivity were modelled as a function of psychopathology and psychomotor outcomes at 18 months. Better psychomotor functioning in toddlerhood was associated with greater relative right cerebellar volume and a more rapid decrease over time of sensorimotor degree centrality in the neonatal period. In contrast, increased 18-month psychopathology was associated with a more rapid decrease in relative regional subcortical volume. Furthermore, while socio-economic deprivation was related to both psychopathology and psychomotor outcomes, cognitively stimulating parenting predicted psychopathology only. Our study highlights the importance of longitudinal imaging to better predict toddler outcomes following preterm birth, as well as disparate environmental influences on separable facets of behavioural development in this population. |
| first_indexed | 2024-03-13T05:03:16Z |
| format | Article |
| id | doaj.art-d537a5e73bbb4bbcb9c26fb7f5e201aa |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-13T05:03:16Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-d537a5e73bbb4bbcb9c26fb7f5e201aa2023-06-17T05:17:58ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-06-0161101250Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birthLucy Vanes0Sunniva Fenn-Moltu1Laila Hadaya2Sean Fitzgibbon3Lucilio Cordero-Grande4Anthony Price5Andrew Chew6Shona Falconer7Tomoki Arichi8Serena J. Counsell9Joseph V. Hajnal10Dafnis Batalle11A. David Edwards12Chiara Nosarti13Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom; Correspondence to: Department of Neuroimaging, De Crespigny Park, London SE5 8AF, United Kingdom.Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, United KingdomWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomBiomedical Image Technologies, TelecomunicacionETSI Telecomunicación, Universidad Politécnica de Madrid & CIBER-BBN, ISCIII, SpainCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King’s College London, United Kingdom; Paediatric Neurosciences, Evelina London Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King’s College London, United KingdomCentre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, United KingdomPreterm birth results in premature exposure of the brain to the extrauterine environment during a critical period of neurodevelopment. Consequently, infants born preterm are at a heightened risk of adverse behavioural outcomes in later life. We characterise longitudinal development of neonatal regional brain volume and functional connectivity in the first weeks following preterm birth, sociodemographic factors, and their respective relationships to psychomotor outcomes and psychopathology in toddlerhood. We study 121 infants born preterm who underwent magnetic resonance imaging shortly after birth, at term-equivalent age, or both. Longitudinal regional brain volume and functional connectivity were modelled as a function of psychopathology and psychomotor outcomes at 18 months. Better psychomotor functioning in toddlerhood was associated with greater relative right cerebellar volume and a more rapid decrease over time of sensorimotor degree centrality in the neonatal period. In contrast, increased 18-month psychopathology was associated with a more rapid decrease in relative regional subcortical volume. Furthermore, while socio-economic deprivation was related to both psychopathology and psychomotor outcomes, cognitively stimulating parenting predicted psychopathology only. Our study highlights the importance of longitudinal imaging to better predict toddler outcomes following preterm birth, as well as disparate environmental influences on separable facets of behavioural development in this population.http://www.sciencedirect.com/science/article/pii/S1878929323000555Preterm birthPsychopathologyPsychomotor functioningLongitudinal imagingRegional volumeDegree centrality |
| spellingShingle | Lucy Vanes Sunniva Fenn-Moltu Laila Hadaya Sean Fitzgibbon Lucilio Cordero-Grande Anthony Price Andrew Chew Shona Falconer Tomoki Arichi Serena J. Counsell Joseph V. Hajnal Dafnis Batalle A. David Edwards Chiara Nosarti Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth Developmental Cognitive Neuroscience Preterm birth Psychopathology Psychomotor functioning Longitudinal imaging Regional volume Degree centrality |
| title | Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth |
| title_full | Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth |
| title_fullStr | Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth |
| title_full_unstemmed | Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth |
| title_short | Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth |
| title_sort | longitudinal neonatal brain development and socio demographic correlates of infant outcomes following preterm birth |
| topic | Preterm birth Psychopathology Psychomotor functioning Longitudinal imaging Regional volume Degree centrality |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323000555 |
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