Predicting the Outcome of Voriconazole Individualized Medication Using Integrated Pharmacokinetic/Pharmacodynamic Model

Predicting the Outcome of Voriconazole Individualized Medication Using Integrated Pharmacokinetic/Pharmacodynamic Model

Therapeutic drug monitoring is considered to be an effective tool for the individualized use of voriconazole. However, drug concentration measurement alone doesn’t take into account the susceptibility of the infecting microorganisms to the drug. Linking pharmacodynamic data with the pharmacokinetic...

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Bibliographic Details
Main Authors: Ping Yang, Wei Liu, Jiajia Zheng, Yuanyuan Zhang, Li Yang, Na He, Suodi Zhai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
voriconazole
individual pharmacokinetic parameters
population pharmacokinetic
Monte Carlo simulation
minimal inhibitory concentration (MIC)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.711187/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.711187/full

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