LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels

LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels

Abstract Background Manipulation of neural stem and progenitor cells (NSPCs) is critical for the successful treatment of spinal cord injury (SCI) by NSPC transplantation, since their differentiation into neurons and oligodendrocytes can be inhibited by factors present in inflamed myelin. In this stu...

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Bibliographic Details
Main Authors: Chen-Guang Zhao, Jie Qin, Jia Li, Shan Jiang, Fen Ju, Wei Sun, Zhen Ren, Yu-Qiang Ji, Rui Wang, Xiao-Long Sun, Xiang Mou, Hua Yuan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
LINGO-1
Neural stem and progenitor cells
Spinal cord injury
Differentiation
Wnt5a
miR-15b-3p
Online Access:https://doi.org/10.1186/s13287-021-02452-0

Internet

https://doi.org/10.1186/s13287-021-02452-0

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