Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα  reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell respon...

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Bibliographic Details
Main Authors: Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner, Luigi Naldini
Format: Article
Language:English
Published: Nature Portfolio 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05315-0

Internet

https://doi.org/10.1038/s41467-018-05315-0

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