Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell respon...
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Bibliographic Details
| Main Authors: |
Giulia Escobar,
Luigi Barbarossa,
Giulia Barbiera,
Margherita Norelli,
Marco Genua,
Anna Ranghetti,
Tiziana Plati,
Barbara Camisa,
Chiara Brombin,
Davide Cittaro,
Andrea Annoni,
Attilio Bondanza,
Renato Ostuni,
Bernhard Gentner,
Luigi Naldini |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-05315-0
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