Exercise attenuates polyglutamine‐mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy

Exercise attenuates polyglutamine‐mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy

Abstract Background Spinal and bulbar muscular atrophy (SBMA) is a hereditary neuromuscular disorder caused by the expansion of trinucleotide cytosine–adenine–guanine (CAG) repeats, which encodes a polyglutamine (polyQ) tract in the androgen receptor (AR) gene. Recent evidence suggests that, in addi...

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Bibliographic Details
Main Authors: Tomoki Hirunagi, Hideaki Nakatsuji, Kentaro Sahashi, Mikiyasu Yamamoto, Madoka Iida, Genki Tohnai, Naohide Kondo, Shinichiro Yamada, Ayuka Murakami, Seiya Noda, Hiroaki Adachi, Gen Sobue, Masahisa Katsuno
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
AMPK
exercise
polyglutamine disease
spinal and bulbar muscular atrophy
Online Access:https://doi.org/10.1002/jcsm.13344

Internet

https://doi.org/10.1002/jcsm.13344

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