HiNT: a computational method for detecting copy number variations and translocations from Hi-C data

HiNT: a computational method for detecting copy number variations and translocations from Hi-C data

Abstract The three-dimensional conformation of a genome can be profiled using Hi-C, a technique that combines chromatin conformation capture with high-throughput sequencing. However, structural variations often yield features that can be mistaken for chromosomal interactions. Here, we describe a com...

Full description

Bibliographic Details
Main Authors: Su Wang, Soohyun Lee, Chong Chu, Dhawal Jain, Peter Kerpedjiev, Geoffrey M. Nelson, Jennifer M. Walsh, Burak H. Alver, Peter J. Park
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Genome Biology
Subjects:
Chromosomal interactions
Structural variation
Whole-genome sequencing
Repetitive region
Online Access:http://link.springer.com/article/10.1186/s13059-020-01986-5

Internet

http://link.springer.com/article/10.1186/s13059-020-01986-5

Similar Items