L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats

L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats

The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The objective of this study was to determine whether th...

Full description

Bibliographic Details
Main Authors: James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Pharmacology
Subjects:
opioids
morphine
naloxone
physical dependence
withdrawal
L-cysteine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1303207/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1303207/full

Similar Items