Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization
Alzheimer’s disease (AD) is a fatal neurodegenerative disorder associated with severe dementia, progressive cognitive decline, and irreversible memory loss. Although its etiopathogenesis is still unclear, the aggregation of amyloid-β (Aβ) peptides into supramolecular structures and their accumulatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8710 |
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| author | Massimiliano Cuccioloni Valentina Cecarini Laura Bonfili Riccardo Pettinari Alessia Tombesi Noemi Pagliaricci Laura Petetta Mauro Angeletti Anna Maria Eleuteri |
| author_facet | Massimiliano Cuccioloni Valentina Cecarini Laura Bonfili Riccardo Pettinari Alessia Tombesi Noemi Pagliaricci Laura Petetta Mauro Angeletti Anna Maria Eleuteri |
| author_sort | Massimiliano Cuccioloni |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a fatal neurodegenerative disorder associated with severe dementia, progressive cognitive decline, and irreversible memory loss. Although its etiopathogenesis is still unclear, the aggregation of amyloid-β (Aβ) peptides into supramolecular structures and their accumulation in the central nervous system play a critical role in the onset and progression of the disease. On such a premise, the inhibition of the early stages of Aβ aggregation is a potential prevention strategy for the treatment of AD. Since several natural occurring compounds, as well as metal-based molecules, showed promising inhibitory activities toward Aβ aggregation, we herein characterized the interaction of an organoruthenium derivative of curcumin with Aβ(1–40) and Aβ(1–42) peptides, and we evaluated its ability to inhibit the oligomerization/fibrillogenesis processes by combining in silico and in vitro methods. In general, besides being less toxic to neuronal cells, the derivative preserved the amyloid binding ability of the parent compound in terms of equilibrium dissociation constants but (most notably) was more effective both in retarding the formation and limiting the size of amyloid aggregates by virtue of a higher hindering effect on the amyloid–amyloid elongation surface. Additionally, the complex protected neuronal cells from amyloid toxicity. |
| first_indexed | 2024-03-09T10:07:53Z |
| format | Article |
| id | doaj.art-d54c92af4ef2401ba4e6558195c45265 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:07:53Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d54c92af4ef2401ba4e6558195c452652023-12-01T22:58:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012315871010.3390/ijms23158710Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) DerivatizationMassimiliano Cuccioloni0Valentina Cecarini1Laura Bonfili2Riccardo Pettinari3Alessia Tombesi4Noemi Pagliaricci5Laura Petetta6Mauro Angeletti7Anna Maria Eleuteri8School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC, ItalySchool of Pharmacy, University of Camerino, Via Sant’Agostino, 62032 Camerino, MC, ItalySchool of Science and Technology, University of Camerino, Via Sant’Agostino, 62032 Camerino, MC, ItalySchool of Pharmacy, University of Camerino, Via Sant’Agostino, 62032 Camerino, MC, ItalySchool of Science and Technology, University of Camerino, Via Sant’Agostino, 62032 Camerino, MC, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC, ItalyAlzheimer’s disease (AD) is a fatal neurodegenerative disorder associated with severe dementia, progressive cognitive decline, and irreversible memory loss. Although its etiopathogenesis is still unclear, the aggregation of amyloid-β (Aβ) peptides into supramolecular structures and their accumulation in the central nervous system play a critical role in the onset and progression of the disease. On such a premise, the inhibition of the early stages of Aβ aggregation is a potential prevention strategy for the treatment of AD. Since several natural occurring compounds, as well as metal-based molecules, showed promising inhibitory activities toward Aβ aggregation, we herein characterized the interaction of an organoruthenium derivative of curcumin with Aβ(1–40) and Aβ(1–42) peptides, and we evaluated its ability to inhibit the oligomerization/fibrillogenesis processes by combining in silico and in vitro methods. In general, besides being less toxic to neuronal cells, the derivative preserved the amyloid binding ability of the parent compound in terms of equilibrium dissociation constants but (most notably) was more effective both in retarding the formation and limiting the size of amyloid aggregates by virtue of a higher hindering effect on the amyloid–amyloid elongation surface. Additionally, the complex protected neuronal cells from amyloid toxicity.https://www.mdpi.com/1422-0067/23/15/8710Alzheimer’s diseaseamyloid-βcurcuminorganoruthenium derivativeanti-aggregating molecule |
| spellingShingle | Massimiliano Cuccioloni Valentina Cecarini Laura Bonfili Riccardo Pettinari Alessia Tombesi Noemi Pagliaricci Laura Petetta Mauro Angeletti Anna Maria Eleuteri Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization International Journal of Molecular Sciences Alzheimer’s disease amyloid-β curcumin organoruthenium derivative anti-aggregating molecule |
| title | Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization |
| title_full | Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization |
| title_fullStr | Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization |
| title_full_unstemmed | Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization |
| title_short | Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization |
| title_sort | enhancing the amyloid β anti aggregation properties of curcumin via arene ruthenium ii derivatization |
| topic | Alzheimer’s disease amyloid-β curcumin organoruthenium derivative anti-aggregating molecule |
| url | https://www.mdpi.com/1422-0067/23/15/8710 |
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