RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner

Abstract Ferroptosis is a form of cell death characterized by lipid peroxidation. Previous studies have reported that knockout of NF-κB activating protein (NKAP), an RNA-binding protein, increased lipid peroxidation level in naive T cells and induced cell death in colon cancer cells. However, there...

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Bibliographic Details
Main Authors: Shicheng Sun, Taihong Gao, Bo Pang, Xiangsheng Su, Changfa Guo, Rui Zhang, Qi Pang
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04524-2