Altered mannose metabolism in chronic stress and depression is rapidly reversed by vitamin B12

Altered mannose metabolism in chronic stress and depression is rapidly reversed by vitamin B12

GDP-Mannose Pyrophosphorylase B (GMPPB) is a key enzyme for glycosylation. Previous studies suggested a dysregulation of GMPBB and mannose in depression. Evidence, however, was sporadic and interventions to reverse these changes are unknown. Here, we show that GMPPB protein, but not RNA abundance is...

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Bibliographic Details
Main Authors: Patricia Franzka, Gustavo Turecki, Susana Cubillos, Takfarinas Kentache, Johann Steiner, Martin Walter, Christian A. Hübner, Olivia Engmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Nutrition
Subjects:
stress
vitamin B12
depression
glycosylation
mannose
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.981511/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2022.981511/full

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