Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris

Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris

Pemphigus Vulgaris (PV) is a life-threatening autoimmune disease manifested with blisters in the skin and mucosa and caused by autoantibodies against adhesion protein desmoglein-3 (Dsg3) expressed in epithelial membrane linings of these tissues. Despite many studies, the pathogenesis of PV remains i...

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Bibliographic Details
Main Authors: Yunying Huang, Hana Jedličková, Yang Cai, Ambreen Rehman, Luke Gammon, Usama Sharif Ahmad, Jutamas Uttagomol, Eric Kenneth Parkinson, Farida Fortune, Hong Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
pemphigus vulgaris
yes-associated protein
oxidative stress
reactive oxygen species
cell-cell adhesion
keratinocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.649502/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.649502/full

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