Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theoretical Studies on Gold Nanoparticles

Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theoretical Studies on Gold Nanoparticles

The use of aromatase inhibitors is an established therapy for estrogen-dependent breast cancer in postmenopausal women. However, the only commercially available aromatase inhibitor, letrozole, is not highly selective; in addition to aromatase, it has an affinity for binding to desmolase, an enzyme i...

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Bibliographic Details
Main Authors: Alaa Edris, Mohammed Abdelrahman, Wadah Osman, Asmaa E. Sherif, Ahmed Ashour, Elrashied A. E. Garelnabi, Sabrin R. M. Ibrahim, Rawan Bafail, Waad A. Samman, Kholoud F. Ghazawi, Gamal A. Mohamed, Abdulrahim A. Alzain
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Metabolites
Subjects:
cancer
aromatase
letrozole analogues
molecular docking
molecular dynamics
gold nanoparticles
Online Access:https://www.mdpi.com/2218-1989/13/5/583

Internet

https://www.mdpi.com/2218-1989/13/5/583

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