Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

Abstract Background Safety evaluation is a prerequisite for nanomaterials in a wide range of fields, including chemical industries, medicine or food sciences. Previously, we had demonstrated that SiNPs could trigger the thrombotic effects in vivo, but the underlying mechanisms remain unknown. This s...

Full description

Bibliographic Details
Main Authors: Lin Feng, Xiaozhe Yang, Shuang Liang, Qing Xu, Mark R. Miller, Junchao Duan, Zhiwei Sun
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Particle and Fibre Toxicology
Subjects:
Silica nanoparticles
Vascular endothelial dysfunction
Blood prethrombotic state
miR-451
IL6R signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12989-019-0300-x

Internet

http://link.springer.com/article/10.1186/s12989-019-0300-x

Similar Items