Chiral Analysis of the Key Intermediates of Tenofovir Alafenamide Fumarate

(R)-Tenofovir phenyl ester ((R)-1) and (R)-tenofovir diphenyl ester ((R)-2) are key intermediates for the practical synthesis of tenofovir alafenamide fumarate, which is a mainstay antiretroviral for the treatment of chronic hepatitis B and HIV-1 infections. This article deals with the chiral analys...

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Bibliographic Details
Main Authors: Man Li, Ting Zhou, Qing-Wen Zhang
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2023-03-01
Series:Pharmaceutical Fronts
Subjects:
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1763512