Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion

Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion

Cocaine is an addictive drug that acts in brain reward areas. Recent evidence suggests that cocaine stimulates synthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in midbrain, increasing dopamine neuron activity via disinhibition. Although a mechanism for cocaine-stimulated 2-AG synthesis...

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Bibliographic Details
Main Authors: Yoki Nakamura, Dilyan I Dryanovski, Yuriko Kimura, Shelley N Jackson, Amina S Woods, Yuko Yasui, Shang-Yi Tsai, Sachin Patel, Daniel P Covey, Tsung-Ping Su, Carl R Lupica
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
ADP-ribosylation factor 6
cannabinoid
dopamine neuron
endosome
guanine nucleotide exchange factor
microvesicle
Online Access:https://elifesciences.org/articles/47209

Internet

https://elifesciences.org/articles/47209

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