Sequence-based Screening for Rare Enzymes: New Insights into the World of AMDases Reveal a Conserved Motif and 58 Novel Enzymes Clustering in Eight Distinct Families.

Sequence-based Screening for Rare Enzymes: New Insights into the World of AMDases Reveal a Conserved Motif and 58 Novel Enzymes Clustering in Eight Distinct Families.

Arylmalonate-Decarboxylases (AMDases, EC 4.1.1.76) are very rare and mostly underexplored enzymes. Currently only four known and biochemically characterized representatives exist. However, their ability to decarboxylate α-disubstituted malonic acid derivatives to optically pure products without cofa...

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Bibliographic Details
Main Authors: Janine Maimanakos, Jennifer Chow, Sarah Gaßmeyer, Simon Güllert, Florian Busch, Robert Kourist, Wolfgang R. Streit
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Microbiology
Subjects:
Decarboxylation
Flurbiprofen
ABC transporters
Hidden Markov Models
racemase
Variovorax sp.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01332/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01332/full

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