A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis

A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis

The etiological underpinnings of amyotrophic lateral sclerosis (ALS) are complex and incompletely understood, although contributions to pathogenesis by regulators of proteolytic pathways have become increasingly apparent. Here, we present a novel variant in UBQLN4 that is associated with ALS and sho...

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Bibliographic Details
Main Authors: Brittany M Edens, Jianhua Yan, Nimrod Miller, Han-Xiang Deng, Teepu Siddique, Yongchao C Ma
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
UBQLN4
beta-catenin
ubiquitin proteasome system (UPS)
ALS
axon morphogenesis
neurodegeneration
Online Access:https://elifesciences.org/articles/25453

Internet

https://elifesciences.org/articles/25453

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