Epigenetically modified AP-2α by DNA methyltransferase facilitates glioma immune evasion by upregulating PD-L1 expression

Epigenetically modified AP-2α by DNA methyltransferase facilitates glioma immune evasion by upregulating PD-L1 expression

Abstract Programmed death-ligand 1 (PD-L1) ensures that tumor cells escape T-cell-mediated tumor immune surveillance. However, gliomas are characteristic of the low immune response and high-resistance therapy, it is necessary to understand molecular regulatory mechanisms in glioblastoma, especially...

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Bibliographic Details
Main Authors: Shengwen Long, Guixiang Huang, Mi Ouyang, Kai Xiao, Hao Zhou, Anyi Hou, Zhiwei Li, Zhe Zhong, Dongmei Zhong, Qinghao Wang, Shuanglin Xiang, Xiaofeng Ding
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05878-x

Internet

https://doi.org/10.1038/s41419-023-05878-x

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