An inflammatory cascade leading to hyperresistinemia in humans.

Obesity, the most common cause of insulin resistance, is increasingly recognized as a low-grade inflammatory state. Adipocyte-derived resistin is a circulating protein implicated in insulin resistance in rodents, but the role of human resistin is uncertain because it is produced largely by macrophag...

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Bibliographic Details
Main Authors: Michael Lehrke, Muredach P Reilly, Segan C Millington, Nayyar Iqbal, Daniel J Rader, Mitchell A Lazar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2004-11-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC529430?pdf=render