Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats

Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats

Summary: Intravenously injected ONO-1301–containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic...

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Bibliographic Details
Main Authors: Shin Yajima, MD, PhD, Shigeru Miyagawa, MD, PhD, Satsuki Fukushima, MD, PhD, Yoshiki Sakai, BSc, Hiroko Iseoka, PhD, Akima Harada, BSc, Kayako Isohashi, MD, PhD, Genki Horitsugi, BSc, Yuki Mori, PhD, Motoko Shiozaki, PhD, Hirotatsu Ohkawara, PhD, Ryoto Sakaniwa, PhD, Jun Hatazawa, MD, PhD, Yoshichika Yoshioka, PhD, Yoshiki Sawa, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19300063

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http://www.sciencedirect.com/science/article/pii/S2452302X19300063

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