NGF receptors and PI3K/AKT pathway involved in glucose fluctuation-induced damage to neurons and α-lipoic acid treatment

NGF receptors and PI3K/AKT pathway involved in glucose fluctuation-induced damage to neurons and α-lipoic acid treatment

Abstract Background Glucose fluctuation promotes neuronal apoptosis, which plays a central role in diabetic encephalopathy (DE). Nerve growth factor (NGF), and its interaction with high-affinity (TrkA) and low-affinity (p75NTR) receptors, are involved in neuronal survival. NGF/TrkA contributes to th...

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Bibliographic Details
Main Authors: Ting Yan, Zhihui Zhang, Danqing Li
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Neuroscience
Subjects:
Diabetic encephalopathy
TrkA
p75NTR
PI3K/AKT
Intermittent high glucose
Cell apoptosis
Online Access:http://link.springer.com/article/10.1186/s12868-020-00588-y

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http://link.springer.com/article/10.1186/s12868-020-00588-y

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