Common themes in PrP signaling: the Src remains the same

The ability of the cellular prion protein (PrPC) to trigger intracellular signals appears central to neurodegeneration pathways, yet the physiological significance of such signals is rather puzzling. For instance, PrPC deregulation disrupts phenomena as diverse as synaptic transmission in mammals an...

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Bibliographic Details
Main Authors: Katharina eOchs, Edward eMálaga-Trillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00063/full