Novel Histone-Based DNA Carrier Targeting Cancer-Associated Fibroblasts

Novel Histone-Based DNA Carrier Targeting Cancer-Associated Fibroblasts

Nuclear proteins, like histone H2A, are promising non-viral carriers for gene delivery since they are biocompatible, biodegradable, bear intrinsic nuclear localization signal, and are easy to modify. The addition of surface-protein-binding ligand to histone H2A may increase its DNA delivery efficien...

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Bibliographic Details
Main Authors: Alexey Kuzmich, Olga Rakitina, Dmitry Didych, Victor Potapov, Marina Zinovyeva, Irina Alekseenko, Eugene Sverdlov
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Polymers
Subjects:
histone H2A
cancer-associated fibroblasts
gene therapy
targeted gene delivery
internalization
receptor-mediated endocytosis
Online Access:https://www.mdpi.com/2073-4360/12/8/1695

Internet

https://www.mdpi.com/2073-4360/12/8/1695

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