Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7

Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7

Although a loss-of-function type mutation was identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we found a DJ-1 modulator UCP0054278 by in silico virtual screening. In this study, we determined the neuro...

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Bibliographic Details
Main Authors: Takashi Yanagida, Yoshihisa Kitamura, Koichiro Yamane, Kazunori Takahashi, Kazuyuki Takata, Daijiro Yanagisawa, Hiroyuki Yasui, Takashi Taniguchi, Takahiro Taira, Toshio Honda, Hiroyoshi Ariga
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319312678

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http://www.sciencedirect.com/science/article/pii/S1347861319312678

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