Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7
Although a loss-of-function type mutation was identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we found a DJ-1 modulator UCP0054278 by in silico virtual screening. In this study, we determined the neuro...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319312678 |
| _version_ | 1811322873687572480 |
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| author | Takashi Yanagida Yoshihisa Kitamura Koichiro Yamane Kazunori Takahashi Kazuyuki Takata Daijiro Yanagisawa Hiroyuki Yasui Takashi Taniguchi Takahiro Taira Toshio Honda Hiroyoshi Ariga |
| author_facet | Takashi Yanagida Yoshihisa Kitamura Koichiro Yamane Kazunori Takahashi Kazuyuki Takata Daijiro Yanagisawa Hiroyuki Yasui Takashi Taniguchi Takahiro Taira Toshio Honda Hiroyoshi Ariga |
| author_sort | Takashi Yanagida |
| collection | DOAJ |
| description | Although a loss-of-function type mutation was identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we found a DJ-1 modulator UCP0054278 by in silico virtual screening. In this study, we determined the neuroprotective effects of UCP0054278 against focal ischemia-induced neurodegeneration in rats. Hydrogen peroxide–induced cell death and the production of reactive oxygen species were significantly inhibited by UCP0054278 in normal SH-SY5Y cells, but not in DJ-1–knockdown cells. These results suggest that UCP0054278 interacts with endogenous DJ-1 and then exhibits antioxidant and neuroprotective responses. Keywords:: DJ-1 modulator, anti-oxidative effect, neuroprotection |
| first_indexed | 2024-04-13T13:43:54Z |
| format | Article |
| id | doaj.art-d571d4b8b6fb479f90ecc2164502904d |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-13T13:43:54Z |
| publishDate | 2009-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-d571d4b8b6fb479f90ecc2164502904d2022-12-22T02:44:32ZengElsevierJournal of Pharmacological Sciences1347-86132009-01-011093463468Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7Takashi Yanagida0Yoshihisa Kitamura1Koichiro Yamane2Kazunori Takahashi3Kazuyuki Takata4Daijiro Yanagisawa5Hiroyuki Yasui6Takashi Taniguchi7Takahiro Taira8Toshio Honda9Hiroyoshi Ariga10Department of Neurobiology, Kyoto 607-8414, JapanDepartment of Neurobiology, Kyoto 607-8414, Japan; Corresponding authors. *a yo-kita@mb.kyoto-phu.ac.jp *b hiro@pharm.hokudai.ac.jpDepartment of Neurobiology, Kyoto 607-8414, JapanFaculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142-8501, JapanDepartment of Neurobiology, Kyoto 607-8414, JapanDepartment of Neurobiology, Kyoto 607-8414, JapanDepartment of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8414, JapanDepartment of Neurobiology, Kyoto 607-8414, JapanDepartment of Molecular Cell Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo 409-3898, JapanFaculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142-8501, JapanDepartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan; Corresponding authors. *a yo-kita@mb.kyoto-phu.ac.jp *b hiro@pharm.hokudai.ac.jpAlthough a loss-of-function type mutation was identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we found a DJ-1 modulator UCP0054278 by in silico virtual screening. In this study, we determined the neuroprotective effects of UCP0054278 against focal ischemia-induced neurodegeneration in rats. Hydrogen peroxide–induced cell death and the production of reactive oxygen species were significantly inhibited by UCP0054278 in normal SH-SY5Y cells, but not in DJ-1–knockdown cells. These results suggest that UCP0054278 interacts with endogenous DJ-1 and then exhibits antioxidant and neuroprotective responses. Keywords:: DJ-1 modulator, anti-oxidative effect, neuroprotectionhttp://www.sciencedirect.com/science/article/pii/S1347861319312678 |
| spellingShingle | Takashi Yanagida Yoshihisa Kitamura Koichiro Yamane Kazunori Takahashi Kazuyuki Takata Daijiro Yanagisawa Hiroyuki Yasui Takashi Taniguchi Takahiro Taira Toshio Honda Hiroyoshi Ariga Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7 Journal of Pharmacological Sciences |
| title | Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7 |
| title_full | Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7 |
| title_fullStr | Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7 |
| title_full_unstemmed | Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7 |
| title_short | Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7 |
| title_sort | protection against oxidative stress induced neurodegeneration by a modulator for dj 1 the wild type of familial parkinson s disease linked park7 |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319312678 |
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