ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations

ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations

Melanoma is the main cause of skin cancer deaths, with special emphasis in those cases carrying BRAF mutations that trigger the mitogen-activated protein kinases (MAPK) signaling and unrestrained cell proliferation in the absence of mitogens. Current therapies targeting MAPK are hindered by drug res...

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Bibliographic Details
Main Authors: Javier Moral-Sanz, Manuel A. Fernandez-Rojo, Jeremy Potriquet, Pamela Mukhopadhyay, Andreas Brust, Patrick Wilhelm, Taylor B. Smallwood, Richard J. Clark, Bryan G. Fry, Paul F. Alewood, Nicola Waddell, John J. Miles, Jason P. Mulvenna, Maria P. Ikonomopoulou
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Toxins
Subjects:
melanoma BRAF mutation
cancer
combination-therapies
venom-peptide
octopus-peptide
Online Access:https://www.mdpi.com/2072-6651/13/2/146

Internet

https://www.mdpi.com/2072-6651/13/2/146

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